The Effect of Diclofenac Sodium on Callus Formation in White Male Rat (Rattus norvegicus) Cruris Fracture Healing

Highlights: Sodium diclofenac is one of NSAID a common treatment to relieve pain associated with bone fractures. some dose body weight could decrease the callus quality on fracture healing. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), such as sodium, are standard treatments The healing process consists four stages: inflammation, soft formation, complex and remodeling. Previous studies mentioned that intake NSAIDs (sodium diclofenac) inhibit process. This study examined effect sodium formation in In this study, thirty-six rats (Rattus Norvegicus) fractures were used divided into two groups, namely 18 for control group. group, each rat was given 1.8 mg diclofenac/150 grams per day. CMC-Na 0.5% equal volume After 28 days, all stunned until dead, diameter strength their calluses measured. group sodium1.8 mg/ 150 BW/ days after tibia pressed using Shimadzu tool, lowest found be 56.500 N, highest 59.000 N. 4 mm, 5 mm. 76 77 6 8 strongest sixth observation, value 59 N 7-8 These measurements 5th, 7th, 8th, 9th, 16th, 17th observations. Diclofenac mg/150 parameters,